committee

Members

Shunbin Ning

Associate Professor

Biography

Dr. Ning was born in China. He received his B.S. and PhD in Cell Biology and Genetics from Wuhan University, a famous university ranked in Top 10 in China. After postdoctoral training at UNC Chapel Hill, he began his independent career at the University of Miami in 2009. He currently is an Assistant Professor of Internal Medicine. He also serves as a member of the faculty panel for education at University of Central Florida.

Dr. Ning is interested in the interaction between EBV and the host innate immune system. EBV is a fascinating paradigm for studying the host-pathogen interaction. Dysregulation of EBV-specific immune response is not only important for EBV latency and oncogenesis, but also a characteristic of EBV-associated autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Current Research

  • Regulation and function of IRFs in innate immunity and EBV latency
  • Evasion of innate immune response by EBV infection
  • Interaction between EBV and host ubiquitin system

Interested topics

  • Immune evasion
  • Interaction between immune and cancer
  • Viral persistence
  • Signal transduction mechanisms in cancer and immune responses

             1999       Top graduate student of Wuhan University

·            1999       Awardfrom Chinese Academy of Sciences

·            2000       Top graduate student of Wuhan University

·            2000       Award fromCommercial Bank of China

·            2000       Award from the NSF of China (Beijing, China. No. 30070376. Role: co-PI)

·            2001       Top graduate student of Wuhan University

·            2001       AwardfromBaogang Education Fund

·            2001       Award fromWandai Education Fund

·            2001       Award from the International Foundation for Science (IFS) (Stockholm. No. C/3187-1. role: PI)

·            2002       Top graduate student of Wuhan University

·            2002       Awardfrom Guilin Sanjin Fund

·            2003       Excellent PhD Thesis Award of Wuhan University

·            2005       Excellent PhD Thesis Award of the Ministry of Education of China

·            2009       Award from the ASM International Professorship Program

·            2011       Outstanding Service to the International Board of the ASM

·            2011       Outstanding Service as an Online Mentor of the ASM Minority Mentoring Program

  •                   2011-2015       World Journal of Virology
  •                   2012-   Journal of Oncobiomarkers
  •                   2012-   Journal of Microbiology & Microbial Technology
  •                   2013-   Autoimmune Diseases & Therapeutic Approaches
  •                   2014-   Journal of Medical Genomics and Biomarkers
  •                   2014-   Journal of Cancer Biology & Treatment
  •                   2015-   Journal of Infectious Diseases and Treatment
  1. Zhou J*, Yang X*, Ning S*, Wang L, Wang K, Zhang Y, Yuan F, Li F, Zhuo D, Tang L, Zhuo D. Identification of KANSARL as the First Cancer Predisposition Fusion Gene Specific to the Population of European Ancestry Origin. Oncotarget. 2017. (In press). * Contributed equally to this project
  2. Wang L, Wang Y, Zhao J, Ren J, Hall KH, Moorman JP, Yao ZQ, Ning S*. LUBAC modulates LMP1 activation of NFκB and IRF7. Journal of Virology. 2017. 91(4): e1138-16. PMID: 27903798
  3. Wang L, Ren J, Li G, Moorman JP, Yao ZQ, Ning S*.LMP1 Signaling Pathway Activates IRF4 in Latent EBV Infection and A Positive Circuit between PI3K and Src Is Required. Oncogene. 2017. Advance online publication 7 November 2016; doi: 10.1038/onc.2016.380. PMID: 27819673
  4. Wang L, Zhao J, Ren J, Hall KH, Moorman JP, Yao ZQ, Ning S*. Protein Phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity. European Journal of Immunology. 2016. 46(10):2409-2419. PMID: 27469204
  5. Wang L, Zhao J, Ren JP, Wu XY, Morrison ZD, Elgazzar MA, Ning S, Moorman JP, Yao ZQ. Expansion of myeloid-derived suppressor cells promotes differentiation of regulatory T cells in HIV-1+ individuals. AIDS. 2016. 30(10):1521-1531. PMID: 26959508.
  6. Ning S, Wang L. Inactivation of type I IFN Jak-STAT pathway in EBV latency. J. Can. Biol. Treat. 2016. 3: 009. Full Text
  7. Zhou Y, Li GY, Ren JP, Wang L, Zhao J, Ning S, Zhang Y, Lian JQ, Huang CX, Jia ZS, Moorman JP, Yao ZQ. Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via ΔNp63-miR-181a-Sirt1 pathway. J Leukoc Biol. 2016.100(5):1201-1211. PMID: 27354409
  8. Ren JP, Wang L, Zhao J, Wang L, Ning S, El Gazzar M, Moorman JP, Yao ZQ. Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection. Immunology. 2017. 150(2):213-220. PMID: 27753084
  9. Ren J, Ying R, Cheng Y, Wang L, Elgazzar M, Li G, Ning S, Moorman J, Yao Z. HCV-induced miR146a controls SOCS1/STAT3 and cytokine expression in monocytes to promote regulatory T cell development. 2016. J Viral Hepat. 23(10):755-766. PMID: 27004559.
  10. Ren, J; Zhao, J; Griffin, J ; Wang, L; Wu, X; Morrison, Z; Li, G; El Gazzar, M; Ning, S; Moorman, J; Yao, Z. Hepatitis C virus-induced myeloid-derived suppressor cells regulate T cell differentiation and function via the STAT3 pathway. Immunology. 2016. 148: 377-386. PMID: 27149428
  11. Yuan F, Dutta T, Wang L, Song L, Gu L, Qian L, Benitez A, Ning S, Malhotra A, Deutscher MP, Zhang Y. Human DNA exonuclease TREX1 is also an exoribonuclease that acts on single-stranded RNA. J. Biol. Chem. 2015. 290(21):13344-53 PMID: 25855793.
  12. Wang L, Yao Z, Jonathan M, Xu Y, Ning S. Gene expression profiling identifies IRF4-associated molecular signatures in hematological malignancies. PLoS One. 2014. 9(9):e106788. PMID: 25207815
  13. Wang L, Ning S. IRF4 is activated through c-Src-mediated tyrosine phosphorylation in virus-transformed cells *. Journal of Virology. 2013. 87(17): 9672-9679. PMID: 23804646
    * Chosen for “Spotlight “ by the editors
  14. Wang L, Toomey NL, Diaz LA, Walker G, Ramos JC, Barber GN, Ning S. Oncogenic IRFs provide a survival advantage for EBV- or HTLV1- transformed cells through induction of BIC expression. Journal of Virology. 2011. 85(16): 8328-8337. PMID: 21680528
  15. Ning S*, Pagano J. The A20 deubiquitinase activity negatively regulates ubiquitination-mediated LMP1 activation of IRF7. J. Virol. 2010. 84(12): 1630-1638. PMID: 20392859
    * Corresponding author
  16. Whitehurst C, Ning S, Bentz G, Dufour F, Gershburg E, Shackelford J, Langelier Y, Pagano J. The EBV deubiquitinating enzyme, BPLF1, reduces EBV ribonucleotide reductase activity. J Virol. 2009. 83(9): 4345-4353. PMID: 19244336
  17. Shunbin Ning, Alex Campos, Bryant Darnay, Gretchen Bentz, Joseph Pagano. TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the TNFR family member LMP1. Molecular and Cellular Biology. 2008. 28(20): 6536-6546. PMID: 18710948
  18. Leslie Huye *, Shunbin Ning*, Michelle Kelliher, Joseph Pagano. IRF7 is activated by a viral oncoprotein through RIP-dependent ubiquitination. Molecular and Cellular Biology. 2007. 27(8): 2910-2918. (* Contributed equally to the work). PMID: 17296724
  19. Shunbin Ning, Leslie Huye, Joseph Pagano. Interferon regulatory factor 5 represses expression of the EBV oncoprotein LMP1: Braking of IRF7/LMP1 regulatory circuit. Journal ofVirology. 2005. 79(18): 11671-11676. PMID: 16140744
  20. Hahn AM, Huye LE, Ning SB, Webster-Cyriaque J, Pagano JS. Interferon regulatory factor-7 is negatively regulated by the Epstein-Barr virus immediate-early gene, BZLF-1.Journal of Virology. 2005. 79(15): 10040-10052. PMID: 16014964
  21. Shunbin Ning, Leslie Huye, Joseph Pagano. Regulation of the transcriptional activity of the IRF7 promoter by a pathway independent of interferon signalling.Journal of Biological Chemistry.2005. 280 (13): 12262-12270. PMID: 15664995
  22. Shunbin Ning, Angela M.Hahn, Leslie HuyeE, Joseph Pagano. Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: A regulatory circuit.Journal of Virology.2003. 77(17): 9359-9368. PMID: 12915551
  23. Ling Wang, Guangyu Li, Zhi Q. Yao, Jonathan Moorman, Shunbin Ning. MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV. Reviews in Medical Virology. 2015. 25: 320-341. Aug 10. doi: 10.1002/rmv.1850. [Epub ahead of print]. PMID: 26258805
  24. Ning S. Interferon Regulatory Factors and Autoimmune Diseases. Journal of Medical Genomics and Biomarkers. 2014. 1:001.
  25. Ning S. IRF4 as an oncogenic biomarker for hematological malignancies. Journal of Oncobiomarkers. 2013. 1(1):6.
  26. Ning S*, Pagano J,Barber G. IRF7: activation, regulation, modification and function. Genes & Immunity. 2011. 12(6): 399-414. PMID: 21490621
    * Corresponding author
  27. Ning S. Innate immune modulation in EBV infection. Herpesviridae. 2011. 2(1):1. PMID: 21429244

 

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