Ph.D. in Life Science from National Defense Medical Center, Taipei., Taiwan, 2001.

M.S. in Biochemistry from National Defense Medical Center, Taipei, Taiwan, 1997.

B.S. in Nutrition and Food Sciences from Fu Jen Catholic University, Taipei, Taiwan,1995

Current Research

• Inflammatory signaling in inflammation, inflammatory diseases and cardiovascular diseases
• Metabolomics research on inflammation and metabolic disorders
• Crosstalk between tumor-associated macrophages and cancer cells in tumor microenvironment

Interested Topics

• Inflammation and Metabolic stress
• Cardiovascular Metabolism
• Metabolism in tumor microenvironment

• Prof. Tian-Li Wang and DistinguishedProf. Ie-Ming Shih (Departments of Gynecology/Obstetrics and Pathology and  Sidney Kimmel Comprehensive Cancer Center
  Johns Hopkins University School of Medicine): Chemoprevention potential of  tryptophan metabolites in preventing ovarian cancer genesis

Publications (2014-present)

1. Jhen-Wei Ruan, Sarah Statt, Chih-Ting Huang, Yi-Ting Tsai, Cheng-Chin Kuo, Hong-Lin Chan, Yu-Chieh Liao, Tse-Hua Tan, and Cheng-Yuan Kao. (2016) Dual-specificity phosphatase 6 deficiency regulates gut microbiome and transcriptome response against diet-induced obesity in mice. Nature Microbiology. doi: 10.1038/nmicrobiol.2016.220.
2. Ling-Yun Chu, Yi-Fu Wang, Huei-Hsuan Cheng, Cheng-Chin Kuo and Kenneth K. Wu (2016). Endothelium-Derived 5-Methoxytryptophan Protects Endothelial Barrier Function by Blocking p38 MAPK Activation. PLoS One, 11(3): e0152166.
3. Yen-Chun Ho, Meng-Ling Wu, Pei-Yu Gung, Chung-Huang Chen, Cheng-Chin Kuo and Shaw-Fang Yet (2016). Heme oxygenase-1 deficiency exacerbates angiotensin II-induced aortic aneurysm in mice. Oncotarget. doi: 10.18632/oncotarget.11917.
4. Yen-Hung Lin, Cheng-Chin Kuo, Chii-Ming Lee, Chia-Hung Chou, Ying-Hsien Chen, Ji-Fan Yeh, Ching-Chang Huang, Chi-Shen Hung, Li-Yu Daisy Liu, Yi-Lwun Ho and Kenneth K. Wu (2016). 5-methoxytryptophan is a potential marker for post-myocardial infarction heart failure- a preliminary approach to clinical utility. International Journal of Cardiology, 222:895-900.
5. Jing-Yi Chen, You-Syuan Lai, Hui-Jen Tsai, Cheng-Chin Kuo, B. Linju Yen, Su-Peng Yeh, H. Sunny Sun and Wen-Chun Hung (2016). The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. scientific reports, 31(6):32428.
6. Huei-Hsuan Cheng, Ling-Yun Chu, Li-Yi Chiang, Hua-Ling Chen, Cheng-Chin Kuo and Kenneth K. Wu (2016). Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan. Oncotarget, 7(21):31243-56.
7. Yen-Chun Ho, Meng-Ling Wu, Chen-Hsuan Su, Chung-Huang Chen, Hua-Hui Ho, Guan-Lin Lee, Wei-Shiang Lin, Wen-Yu Lin, Yu-Juei Hsu, Cheng-Chin Kuo, Kenneth K. Wu and Shaw-Fang Yet (2016). A novel protective function of 5 methoxytryptophan in Vascular Injury. Scientific Reports, 6:25374. doi: 10.1038/srep25374.
8. Pinpin Lin, Yi-Rong Chen, Chao-Yu Chen, Ya-Ting Chang, Jhih-Sheng Chen, Ming-Hsien Tsai, Cheng-Chin Kuo and Hui-Ling Lee (2016). Changes of serum amino acid profiles by an epidermal growth factor receptor mutation and benzo[a]pyrene in mouse lung tumorigenesis. Toxicology Research, 5: 1182-1192.
9. Guan-Lin Lee, Jing-Yiing Wu, Chien-Sung Tsai, Chih-Yuan Lin, Yi-Ting Tsai, Chin Sheng Lin, Yi-Fu Wang, Shaw-Fang Yet, Yu-Juei Hsu and Cheng-Chin Kuo* (2016). TLR4-Activated MAPK-IL-6 Axis Regulates Vascular Smooth Muscle Cell Function. International Journal of Molecular Sciences, 17(9). pii: E1394. (Corresponding author).
10. Yi-Fu Wang, Yu-Juei Hsu, Hsu-Feng Wu,Guan-Lin Lee, Ya-Sung Yang, Jing-Yiing Wu, Shaw-Fang Yet, Kenneth K. Wu* and Cheng-Chin Kuo* (2016). Endothelium-derived 5-methoxytryptophan is a circulating anti-inflammatory molecule that blocks systemic inflammation. Circulation Research, 119(2):222-36. (* Corresponding author).
11. Guan-Lin Leea, Jing-Yiing Wu, Chang-Ching Yeha and Cheng-Chin Kuo* (2016). TLR4 induces CREB-mediated IL-6 production via upregulation of Fspondin to promote vascular smooth muscle cell migration. Biochemical andBiophysical Research Communications, 473(4):1205-10. (Corresponding author).
12. Yi-Fu Wang, Guan-Lin Lee, Yu-Hua Huang and Cheng-Chin Kuo* (2016). sn-1,2-diacylglycerols protect against lethal endotoxemia by controlling systemic inflammation. Immunobiology, 221(11):1309-18. (Corresponding author).
13. Jing-Yiing Wu and Cheng-Chin Kuo* (2015). ADP-ribosylation factor 3 mediates cytidine-phosphate-guanosine oligodeoxynucleotide-induced responses by regulating Toll-Like receptor 9 trafficking. Journal of InnateImmunity, 7(6):623-636. (Corresponding author).
14.  Ling-Yun Chu, Yi-Fu Wang, Huei-Hsuan Cheng, Cheng-Chin Kuo and Kenneth K. Wu (2016). Endothelium-Derived 5-Methoxytryptophan Protects Endothelial Barrier Function by Blocking p38 MAPK Activation. PLoS One, 11(3): e0152166.
15. Ya-Ting Cheng, Dong-Feng Yeih, Shu-Man Liang, Chia-Ying Chien, Yen-Ling Yu, Bor-Sheng Ko, Yee-Jee Jan, Cheng-Chin Kuo, Li-Ying Sung, Song-Kun Shyue, Ming-Fong Chen, Shaw-Fang Yet, Kenneth K. Wu and Jun-Yang Liou (2015). Rho-associated kinase inhibitors promote the cardiac differentiation of embryonic and induced pluripotent stem cells. International Journal ofCardiology, 201:441-448.
16.  Pei-Hsuan Lin, Hsien-Yi Lin, Cheng-Chin Kuo and Liang-Tung Yang (2015). N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting. Journal of Biomedical Science, 22:44.
17.  Jing-Yi Chen, Chien-Feng Li, Cheng-Chin Kuo, Kelvin K Tsai, Ming-Feng Hou and Wen-Chun Hung (2014). Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression. BreastCancer Research, 16(4):410. 
18. Huei-Hsuan Cheng, Kai-Hsuan Wang, Ling-yun Chu, Tzu-Ching Chang, Cheng-Chin Kuo and Kenneth K. Wu (2014). Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production. PLoS One, 9(2): e8850