Ph.D. - in Statistics, May 2006.
Purdue University, West Lafayette, IN, USA.

M.S.  -in Statistics, May 2002.
Purdue University, West Lafayette, IN, USA.

B.S. - in Statistics, June 1998.
Nankai University, Tianjin, China.

Honors and Awards

JiuZhang Mathematics Scholarship Award, Nankai University, 1996
Wang Kechang Scholarship Award, Nankai University, 1997

Journal Articles
1. Crawford M, Brawner E, Batte K, Yu L, Hunter MG, Otterson GA, Nuovo G, Marsh
CB, Nana-Sinkam S P. "MicroRNA-126 inhibits invasion in non-small cell lung carcinoma
cell lines." Biochemical And Biophysical Research Communications, 2008; 373:607-612.
2. Lesinski GB, Trefry J, Brasdovich M, Kondadasula SV, Sackey K, Zimmerer JM, Chaud-
hury AR, Yu L, Zhang X, Crespin TR, Walker MJ, Carson WE 3rd. "Melanoma cells
exhibit variable signal transducer and activator of transcription 1 phosphorylation and
a reduced response to IFN-alpha compared with immune eector cells." Clinical Cancer
Research, 2007; 13(17):5010-5019.
3. Jacob A, Robinson LL Jr, Bortman JS, Yu L, Dodson EE, Welling DB. "Nerve of origin,
tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma
resections at a tertiary care academic center." Laryngoscope. 2007;117(12):2087-2092.
4. Jacob A, Bortman JS, Robinson LL Jr, Yu L, Dodson EE,Welling DB. "Does packing the
eustachian tube impact cerebrospinal uid rhinorrhea rates in translabyrinthine vestibular
schwannoma resections?" Otology and Neurotology, 2007; 28(7):934-938.
5. Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee
ML, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh CB. "Detection of microRNA
expression in human peripheral blood microvesicles." PLoS ONE, 2008; 3(11):e3694.
6. Qian S, Zhong X, Yu L, Ding B, de Haan P, Boris-Lawrie K. "HIV-1 Tat RNA silencing
suppressor activity is conserved across kingdoms and counteracts translational repression
of HIV-1." Proceedings of the National Academy of Sciences USA, 2009; 106(2):605-610.
7. Dworkin AM, Tober KL, Duncan FJ, Yu L, VanBuskirk AM, Oberyszyn TM, Toland AE.
"Chromosomal aberrations in UVB-induced tumors of immunosuppressed mice." Genes
Chromosomes and Cancer, 2009; 48(6):490-501.
8. Crawford M, Batte K, Yu L, Wu X, Nuovo GJ, Marsh CB, Otterson GA, Nana-Sinkam
SP. "MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer."
Biochemical And Biophysical Research Communications, 2009; 388(3):483-489
9. Li M, Kesic M, Yin H, Yu L, Green PL. "Kinetic analysis of human T-cell leukemia
virus type 1 gene expression in cell culture and infected animals." Journal Virology, 2009;
83(8):3788-3797.3
10. Bolinger C, Sharma A, Singh D, Yu L, Boris-Lawrie K. "RNA helicase A modulates
HIV-1 translation and infectivity." Nucleic Acids Research, 2010; 38:1686-1696.
11. Hayenes II R, Ware E, Premanandan C, Zimmerman B, Yu L, Phipps AJ and Lairmore
MD. "Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection
in a rabbit model." Blood, 2010; 115(4):815-823.
12. Haynes II R, Zimmerman B, Millward L,Ware E, Premanandan C, Yu L, Phipps AJ, and
Lairmore MD. "Early Spatial and Temporal Events of Human T-lymphotropic virus type
1.Spread Following Blood Borne Transmission in a Rabbit Model of Infection." Journal
of Virology, 2010; 84(10):5124-5130.
13. Yu L and Doerge RW "A semi-nonparametric approach for selecting functionally consis-
tent proteins in protein microarray experiments." BMC Bioinformatics, 2010; 11:486
14. Dmitrieva N, Yu L, Viapiano M, Cripe T, Chiocca EA, Glorioso J, Kaur B. "Choin-
droitinase ABC I enhances intra-tumor distribution and anti-tumor ecacy of oncolytic
virus." Proceedings of the National Academy of Sciences USA, 2010.
15. Chen S, Claus R, Yu L, Qian J, Ruppert AS, Lucas DM,West DA, Williams KE, Johnson
AJ, Sablitzky F, Larson RA, Plass C, Byrd JC. "Silencing of the inhibitor of DNA binding
protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL." Blood, 2010.
16. Hsu S, Wang B, Bai S, Kutay H, Costinean S, Yu L, Nuovo G, Jacob S, Ghoshal
K. "MicroRNA-122 knockout mice develop spontaneous microsteatosis, hepatitis and
diethylnitrosamine-induced hepatocellular carcinoma." Journal of Clinical Investigation,2010.
17. Deol YS, Nasser MW, Yu L, Zou X, Ganju RK. "Tumor suppressive eects of psoriasin
(S100A7) are mediated through beta-catenin/TCF4 pathway in estrogen receptor positive
breast cancer cells." Journal of Biological Chemistry, 2011;286:44845-44854.
18. Yu L, Gulati P, Fernandez S, Pennell M, Kirschner L, Jarjoura D. "Fully moderated t-
statistic for small sample size gene expression arrays." Statistical Applications in Genetics
and Molecular Biology, 2011; 10:article 42.
19. Souba W, Notestine M, Way D, Lucey C, Yu L, Sedmak D. "Do deans and teaching
hospital CEOs agree on what it takes to be a successful clinical department chair?"
Academic Medicine, 2011; 86:974-981.
20. Li R, Ackerman WE, Summereld TL, Yu L, Gulati P, Zhang J, Huang K, Romero R,
Kniss DA. "In ammatory gene regulatory networks in amnion cells following cytokine
stimulation: translational systems approach to modeling human parturition." PLoS One,2011; 6:e20560.
21. Schloss B, Gulati P, Yu L, Abdel-Rasoul M, O'Brien W, Von Visger J, Awad H. "Impact
of aprotinin and renal function on mortality: A retrospective single center analysis."
Journal of Cardiothoracic Surgery, 2011; 6:103.
22. Hayes A, Qian S, Yu L, Boris-Lawrie K. "Tat RNA silencing suppressor activity con-
tributes to perturbation of lymphocyte miRNA by HIV-1." Retrovirology, 2011; 8:36.4
23. Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KMD,
Kirschner LS. "Rac1 is required for Prkar1a-mediated Nf2 supression in Schwann cell
tumors." Oncogene, 2012.
24. Claus R, Lucas DM, Stilgenbauer S, Ruppert AS, Yu L, Zucknick M, Mertens D, Buhler
A, Oakes CC, Larson RA, Kay NE, Jelinek DF, Kipps TJ, Rassenti LZ, Gribben JG,
Dohner H, Heerema NA, Marcucci G, Plass C, Byrd JC. "Quantitative DNA methyla-
tion analysis identies a single CpG dinucleotide important for ZAP-70 expression and
predictive of prognosis in chronic lymphocytic leukemia." Journal of Clinical Oncology,2012; 30:2483-2491.
25. Hsu S, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula
RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell J, Ghoshal
K. "Essential metabolic, anti-in ammatory, and anti-tumorigenic functions of miR-122 in
liver." Journal of Clinical Investigation, 2012; 122:2871-2883.
26. Kutay H, Klepper C, Wang B, Hsu S, Datta J, Yu L, Zhang X, Majumder S, Motiwala
T, Khan N, Belury M, McClain C, Jacob S, Ghoshal K. "Reduced susceptibility of DNA
methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding
liquid alcohol diet." PLOS One, 2012; 7:e41949.
27. Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srini-
vasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pecot T, Rosol TJ, Cory
S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE,
Chiocca EA, Leone G, Ostrowski MC. "Reprogramming of the tumor microenvironment
by stromal PTEN-regulated miR-320." Nature Cell Biology, 2012; 14:159-167.
28. Haseley A, Boone S, Wojton J, Yu L, Yoo JY, Yu J, Kurozumi K, Glorioso JC, Caligiuri
MA, Kaur B. "Extracellular matrix protein CCN1 limits oncolytic ecacy in glioma."
Cancer Research, 2012; 72:1353-1362.
29. Trotta R, Chen L, Ciarlariello D, Josyula S, Mao C, Costinean S, Yu L, Butchar JP,
Tridandapani S, Croce CM, Caligiuri MA. "miR-155 regulates IFN-r production in natural
killer cells." Blood, 2012; 119:3478-3485.
30. Crouser ED, Julian MW, Crawford M, Shao G, Yu L, Planck SR, Rosenbaum JT, Nana-
Sinkam SP. "Dierential expression of microRNA and predicted targets in pulmonary
sarcoidosis." Biochemical and Biophysical Research Communications, 2012; 417:886-891.
31. Pringle DR, Yin Z, Lee AA, Manchanda PK, Yu L, Parlow AF, Jarjoura D, La Perle
KM, Kirschner LS. "Thyroid-specic ablation of the carney complex gene, PRKAR1A,
results in hyperthyroidism and follicular thyroid cancer." Endocrine-Related Cancer, 2012;19:435-446.
32. Ezzie ME, Crawford M, Cho JH, Orellana R, Zhang SL, Gelinas R, Batter K, Yu L,
Nuovo G, Galas D, Diaz P, Wang K, Nana-Sinkam SP. "Gene expression networks in
COPD: microRNA and mRNA regulation." THORAS, 2012; 67:122-131.
33. Trotta R, Chen L, Costinean S, Josyula S, Mundy-Bosse BL, Ciarlariello D, Mao C,
Briercheck EL, McConnell KK, Mishra A, Yu L, Croce CM, Caligiuri MA. "Overex-
pression of miR-155 causes expansion, arrest in terminal dierentiation and functional
activation of mouse natural killer cells." Blood, 2013.5
34. Wul BC, Yu L, Parent AE, and Wilgus TA. "Novel dierences in the expression of
in ammation-associated genes between mid- and late-gestational dermal broblasts."
Wound Repair Regen, 2013; 21:103-112.
35. Kim MY, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, Longhi S, Girod S, Niewiesk S,
Oglesbee M. "Hsp70 and a novel axis of type I interferon-dependent antiviral immunity
in the measles virus-infected brain." Journal of Virology, 2013; 87:998-1009.
36. Fleming JL, Gable DL, Samadzadeh-Tarighat S, Cheng L, Yu L, Gillespie JL, Toland
AE. "Dierential expression of miR-1, a putative tumor suppressing microRNA, in cancer
resistant and cancer susceptible mice." PeerJ, 2013.
37. Collins AL, Wojcik S, Liu J, Frankel WL, Alder H, Yu L, Schmittgen TD, Croce CM
and Bloomston M. "A dierential microRNA prole distinguishes cholangiocarcinoma
from pancreatic adenocarcinoma." Annals of Surgical Oncology, 2013.
38. Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD,
Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R,
Hallett M, Park M, Leone G and Ostrowski MC. "Ets2 in tumor broblasts promotes
angiogenesis in breast cancer." PLOS One, 2013, 8:e71533.
39. Wallace JA, Pitarresi JR, Sharma N, Palettas M, Cuitino MC, Sizemore ST, Yu L,
Sanderlin A, Rosol TJ, Mehta KD, Sizemore GM, Ostrowski MC. Protein Kinase C Beta
in the tumor microenvironment promotes mammary tumorigenesis. Front Oncol, 2014.
40. Liu MJ, Bao S, Napolitano JR, Durris DL, Yu L, Tridandapani S, Knoell DL. Zinc
regulates the acute phase response and serum amyloid A production in response to sepsis
through JAK-STAT2 signaling. PLoS One, 2014;9(4):e94934.
41. Pringel DR, Vasko VV, Yu L, Manchanda PK, Lee AA, Zhang X, Kirschner JM, Parlow
AF, Saji M, Jarjoura D, Ringel MD, La Perle KM, Kirschner LS. Follicular thyroid cancers
demonstrate dual activation of PKA and mTOR as modeled by thyroid-specic deletion
of Prkar1a and Pten in mice. J Clin Endocrinol Metab, 2014;99(5):E804-812.
42. Wang Y, Jeong Y, Jhiang SM, Yu L, Menq C. Quantitative characterization of cell be-
haviors through cell cycle progression via automated cell tracking. PLOS One, 2014;9(6):e98762.
43. Oghumu S, Terrazas CA, Varikuti S, Kimble J, Vadia S, Yu L, Seveau S, Satoskar AR.
CXCR3 expression denes a novel subset of innate CD8+ T cells that enhance immunity
against bacterial infection and cancer upon stimulation with IL-15. FASEB J, 2014.
44. Werbeck JL, Thudi NK, Martin CK, Premanandan C, Yu L, Ostrowksi MC, Rosol TJ.
Tumor microenvironment regulates metastasis and metastasis genes of mouse MMTV-
PymT mammary cancer cells in vivo. Vet Pathol., 2014;51(4):868-81.
45. Briercheck EL, Trotta R, Chen L, Hartlage AS, Cole JP, Cole TD, Mao C, Banerjee PP,
Hsu HT, Mace EM, Ciarlariello D, Mundy-Bosse BL, Garcia-Cao I, Scoville SD, Yu L,
Pilarski R, Carson WE 3rd, Leone G, Pandol PP, Yu J, Orange JS, Caligiuri MA. PTEN
Is a Negative Regulator of NK Cell Cytolytic Function. J Immunol., 2015; 194(4).6
46. Guzman N, Agarwal K, Asthagiri D, Yu L, Saji M, Ringel MD, Paulaitis ME. Breast
Cancer-Specic miR Signature Unique to Extracellular Vesicles Includes "microRNA-like"
tRNA Fragments. Mol Cancer Res., 2015;13(5):891-901.
47. Drosdeck JM, Osayi SN, Peterson LA, Yu L, Ellison EC, Muscarella P. Surgeon and
nonsurgeon personalities at dierent career points. J Surg Res., 2015 Jun 1;196(1):60-6.
48. Yeh YY, Ozer HG, Lehman AM, Maddocks K, Yu L, Johnson AJ, Byrd JC. Character-
ization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion
by activation of B-cell receptor signaling. Blood, 2015; 125(21):3297-3305.
49. Mani R, Mao Y, Frissora FW, Chiang CL, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X,
Yu L, Flynn J, Jones J, Andritsos L, Baskar S, Rader C, Phelps MA, Chen CS, Lee RJ,
Byrd JC, Lee LJ, Muthusamy N. Tumor antigen ROR1 targeted drug delivery mediated
selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia.
Leukemia, 2015;29(2):346-55.
50. Chen W, Frankel WL, Cronley KM, Yu L, Zhou X, Yearsley MM. Signicance of paneth
cell metaplasia in barrett esophagus: a morphologic and clinicopathologic study. Am J
Clin Pathol., 2015;143(5):665-71.
51. Mathsyaraja H, Thies K, Taany DA, Deighan C, Liu T, Yu L, Fernandez SA, Shapiro
C, Otero J, Timmers C, Lustberg MB, Chalmers J, Leone G, Ostrowski MC. CSF1-
ETS2-induced microRNA in myeloid cells promote metastatic tumor growth. Oncogene,2014.
52. Dakhlallah D, Zhang J, Yu L, Marsh CB, Angelos MG, Khan M. MicroRNA-133a engi-
neered mesenchymal stem cells augment cardiac function and cell survival in the infarct
heart. J Cardiovasc Pharmacol, 2015; 65(3):241-51.
53. Gillespie J, Skeeles LE, Allain DC, Kent MN, Peters SB, Nagarajan P, Yu L, Teknos TN,
Olencki T, Toland AE. MicroRNA expression proling in metastatic cutaneous squamous
cell carcinoma. J Eur Acad Dermatol Venereol, 2015.
54. Caserta E, Egriboz O,Wang H, Martin C, Koivisto C, Pect T, Kladney RD, Shen C, Shim
KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava
A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol
TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O'Malley DM, Backes F, Suarez
AA, Goodfellow P, Chamberlin HM, Macrae ER, Shapiro CL, Ostrowski MC, Leone G.
Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development
in vivo. Genes Dev. 2015 Aug 15;29(16):1707-20.
55. Brathwaite S, Kuhrt M, Yu L, Arnold M, Husain S, Harzman AE. Retrospective Evalua-
tion of Laparoscopic Versus Open Hartmann's Reversal: A Single-Institution Experience.
Surg Laparosc Endosc Percutan Tech. 2015 Oct;25(5):e156-8.
56. Araujo LH, Timmers C, Shilo K, Zhao W, Zhang J, Yu L, Natarajan TG, Miller CJ,
Yilmaz AS, Liu T, Amann J, Lapa E Silva JR, Ferreira CG, Carbone DP. Impact of Pre-
Analytical Variables on Cancer Targeted Gene Sequencing Eciency. PLoS One. 2015
Nov 25;10(11):e0143092.7
57. Parikh SV, Malvar A, Song H, Alberton V, Lococo B, Vance J, Zhang J, Yu L, Rovin
BH. Characterising the immune prole of the kidney biopsy at lupus nephritis are dif-
ferentiates early treatment responders from non-responders. Lupus Sci Med. 2015 Nov
18;2(1):e000112.
58. Yu P, Balkhi M, Ladner K, Alder H, Yu L, Kraybill W, Mo X, Guttridge D, Iwenofu O. A
Selective Screening Platform Reveals Unique Global Expression Patterns of microRNAs in
a Cohort of Human Soft-Tissue Sarcomas. Laboratory Investigation, 2016 Apr;96(4):481-491.
59. Chen TL, Gupta N, Lehman A, Ruppert AS, Yu L, Oakes CC, Claus R, Plass C, Mad-
docks KJ, Andritsos L, Jones JA, Lucas DM, Johnson AJ, Byrd JC, Hertlein E. Hsp90
inhibition increases SOCS3 transcript and regulates migration and cell death in chronic
lymphocytic leukemia. Oncotarget. 2016 Apr 16.
60. Sti A, Trikha P, Wesolowski R, Kendra K, Hsu V, Uppati S, McMichael EL, Duggan M,
Campbell A, Keller K, Landi I, Zhong Y, Dubovsky J, Howard JH, Yu L, Harrington B,
Old M, Rei S, Mace T, Tridandapani S, Muthusamy N, Caligiuri M, Byrd JC, Carson
WE 3rd. Myeloid-derived suppressor cells express Bruton's tyrosine kinase and can be
depleted in tumor bearing hosts by ibrutinib treatment. Cancer Res. 2016 Feb 15.
61. Shapiro JP, Komar HM, Hancioglu B, Yu L, Jin M, Ogata Y, Hart PA, Cruz-Monserrate
Z, Lesinski GB, Conwell DL. Laser Capture Microdissection of Pancreatic Acinar Cells
to Identify Proteomic Alterations in a Murine Model of Caerulein-Induced Pancreatitis.
Clin Transl Gastroenterol. 2017 Apr 13;8(4):e89.
62. Guinn D, Lehman A, Fabian C, Yu L, Maddocks K, Andritsos LA, Jones JA, Flynn JM,
Jaglowski SM, Woyach JA, Byrd JC, Johnson AJ. The regulation of tumor-suppressive
microRNA, miR-126, in chronic lymphocytic leukemia. Cancer Med. 2017 Apr;6(4):778-787.
63. Wang C, Saji M, Justiniano SE, Yusof AM, Zhang X, Yu L, Fernndez S, Wakely P Jr,
La Perle K, Nakanishi H, Pohlman N, Ringel MD. RCAN1-4 is a thyroid cancer growth
and metastasis suppressor. JCI Insight. 2017 Mar 9;2(5):e90651.
64. Datta J, Damodaran S, Parks H, Ocrainiciuc C, Miya J, Yu L, Gardner EP, Samorod-
nitsky E, Wing MR, Bhatt D, Hays J, Reeser JW, Roychowdhury S. Akt Activation
Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398.
Mol Cancer Ther. 2017 Apr;16(4):614-624.
65. Wang Y, He H, Li W, Phay J, Shen R, Yu L, Hancioglu B, de la Chapelle A. MYH9
binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk
locus. Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):474-479.
66. Kautto EA, Bonneville R, Miya J, Yu L, Krook MA, Reeser JW, Roychowdhury S.
Performance evaluation for rapid detection of pan-cancer microsatellite instability with
MANTIS. Oncotarget. 2017 Jan 31;8(5):7452-7463.
67. Hu Z, Xu J, Cheng J, McMichael E, Yu L, Carson WE 3rd. Targeting tissue factor as a
novel therapeutic oncotarget for eradication of cancer stem cells isolated from tumor cell8
lines, tumor xenografts and patients of breast, lung and ovarian cancer. Oncotarget. 2017
Jan 3;8(1):1481-1494.
68. Suarez-Kelly LP, Campbell AR, Rampersaud IV, Bumb A, Wang MS, Butchar JP, Tri-
dandapani S, Yu L, Rampersaud AA, Carson WE 3rd. Fluorescent nanodiamonds engage
innate immune eector cells: A potential vehicle for targeted anti-tumor immunotherapy.
Nanomedicine. 2017 Apr;13(3):909-920.
69. Parikh SV, Malvar A, Song H, Alberton V, Lococo B, Vance J, Zhang J, Yu L, Birm-
ingham D, Rovin BH. Molecular imaging of the kidney in lupus nephritis to characterize
response to treatment. Transl Res. 2017 Apr;182:1-13.
70. Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E,
Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T,
Bloomston M, Bekaii-Saab T, Lesinski GB. IL-6 and PD-L1 antibody blockade combi-
nation therapy reduces tumour progression in murine models of pancreatic cancer. Gut.
2016 Oct 21.
71. Suarez-Kelly LP, Kemper GM, Duggan MC, Sti A, Noel TC, Markowitz J, Luedke
EA, Yildiz VO, Yu L, Jaime-Ramirez AC, Karpa V, Zhang X, Carson WE 3rd. The
combination of MLN2238 (ixazomib) with interferon-alpha results in enhanced cell death
in melanoma. Oncotarget. 2016 Dec 6;7(49):81172-81186.
72. Pitarresi JR, Liu X, Sharma SM, Cuitio MC, Kladney RD, Mace TA, Donohue S, Nayak
SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R,
Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC.
Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during
Acinar-to-Ductal Metaplasia. Neoplasia. 2016 Sep;18(9):541-52.
73. Liu X, Pitarresi JR, Cuitio MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG,
Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S,
Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G,
Wu J, Ostrowski MC. Genetic ablation of Smoothened in pancreatic broblasts increases
acinar-ductal metaplasia. Genes Dev. 2016 Sep 1;30(17):1943-55.
74. Justiniano SE, McElroy JP, Yu L, Yilmaz AS, Coombes KR, Senter L, Nagy R, Wakely
P Jr, Volinia S, Vinco M, Giordano TJ, Croce CM, Saji M, Ringel MD. Genetic variants
in thyroid cancer distant metastases. Endocr Relat Cancer. 2016 Oct;23(10):L33-6.
75. Lee LJ, Yang Z, Rahman M, Ma J, Kwak KJ, McElroy J, Shilo K, Goparaju C, Yu
L, Rom W, Kim TK, Wu X, He Y, Wang K, Pass HI, Nana-Sinkam SP. Extracellular
mRNA Detected by Tethered Lipoplex Nanoparticle Biochip for Lung Adenocarcinoma
Detection. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1431-3.
76. Browning RL, Byrd WH, Gupta N, Jones J, Mo X, Hertlein E, Yu L, Muthusamy N,
Byrd JC. Lenalidomide Induces Interleukin-21 Production by T Cells and Enhances IL21-
Mediated Cytotoxicity in Chronic Lymphocytic Leukemia B Cells. Cancer Immunol Res.
2016 Aug;4(8):698-707.9
77. Chen TL, Gupta N, Lehman A, Ruppert AS, Yu L, Oakes CC, Claus R, Plass C, Mad-
docks KJ, Andritsos L, Jones JA, Lucas DM, Johnson AJ, Byrd JC, Hertlein E. Hsp90
inhibition increases SOCS3 transcript and regulates migration and cell death in chronic
lymphocytic leukemia. Oncotarget. 2016 May 10;7(19):28684-96.
78. Senaras C, Moberly AC, Teknos T, Essig G, Elmaraghy C, Taj-Schaal N, Yu L, Gurcan
M. Autoscope: automated otoscopy image analysis to diagnose ear pathology and use
of clinically motivated eardrum features ", Proc. SPIE 10134, Medical Imaging 2017:
Computer-Aided Diagnosis, 101341X. 2017 March.
79. Yu L, Fernandez S, Brock G. Power analysis for RNA-Seq dierential expression studies.
BMC Bioinformatics, 2017 May;18:234.

Presentations
1. Yu L "Statistical Issues in RNA-Seq Data Analysis". OSU BMI CALIBRE, Feb. 2017.
2. Cannon M, Heinlein M, ElGamal D, Yu L, Kraut E, Lapalombella R, Desai P. Analysis of
miRNA Expression Proles Suggests Possible Biomarkers for Prediction of Allomunization
in Blood Transfused Sickle Cell Disease Patients. ASH 2016.
3. El-Gamal1 D, Ozer G, Powell B, Hing ZA, Blachly JS, Mitchell S, Williams K, Harrington
B, Alinari L, Baiocchi RA, Cannon M, Goettl VM, Woyach JA, Sampath D, Jones JA,
Lehman AM, Yu L, Zhang C, Bollag G, Byrd JC and Lapalombella R. Inhibition of BET
family proteins targets multiple driver genes in CLL. iwCLL 2017.
4. Yu L "Power Analyses for RNA-Seq Dierential Expression Studies." JSM, Aug. 2016.
5. Parikh S, Malvar A, Song H, Vance J, Alberton V, Lococo B, Zhang J, Yu L, Birmingham
D, Rovin BH. "Characterizing the Immune Prole of Serial Kidney Biopsies Dierentiates
Treatment Responders from Non-Responders in Lupus Nephritis" ISN, 2016.
6. ElGamal D, Hing ZA, Mitchell S, LaFollette TD, Brennan PJ, Flynn JM, Jones JA,
Awan F, Andritsos LA, Blackly JS, Williams K, Harrington BK, Geottl VM, Woyach
JA, Lehman AM, Yu L, Byrd JC, Lapalombella R. A novel inhibitor of BET family
bromodomains demonstrates in vivo and in vitro potency in B-Cell Malignancies. ASH,
Orlando, Dec. 2015.
7. Yu L. "Power Analyses for RNA-Seq Dierential Expression." OSU CPH Biostatistics,
Nov. 2015.
8. Yu L. "Predictive Modeling with Omics data." The First OSU Omics Workshop, Sep.
2015.
9. Yeh YY, Ozer HC, Lehman AM, Yu L, Johnson AJ, Byrd JC. "Characterization of
plasma-derived exosomes in CLL reveals a distinct mircoRNA signature and the BCR
regulation in exosome secretion. AACR 106th Annual Meeting, Philadelphia, Apr. 2015.
10
10. Yu L. "Experimental design and sample size calculation for RNA-Seq Studies." OSU
BMI retreat, Mar. 2015.
11. El-Gamal D, LaFollette TD, Lai H, Li C, Sampath D, Lehman A, Yu L, Byrd JC, Baiocchi
RA, Lapalombella R. "Expression of PRMT5 in B-cell chronic lymphocytic leukemia and
its signicance in disease progression and Richter's transformation." 56th ASH Annual
Meeting, San Francisco, CA, Dec. 2014.
12. Parikh S, Song H, Vance J, Zhang J, Yu L, Malvar A, Robin BH. "MOlecular character-
ization of proferative lupus nephritis." Lupus 2014, Quebec City, Sep. 2014.
13. Parikh S, Song H, Kimmel PL, Kusek JW, Zhang J, Yu L, Malvar A, Robin BH. "The
CKD biomarkers consortium dierentiating treatment responders from non-responders
using biomarkers identied from the molecular analysis of lupus nephritis kidney biopsies."
American Society of Nephrology Annual Meeting, Philadelphia, PA, Nov. 2014.
14. Masterson LL, Corby T, Haurani M, Yu L, Starr J. "Access site complications are com-
monly found on femoral artery duplex ultrasound and associated with age and manual
pressure." Midwestern Vascular Surgical Society Annual Meeting, University of IOWA,
Sep. 2014.
15. Alghothani N, Gaillard T, Yu L, Osei K. "African amerian nondiabetic, postmenopausal
woman (AAW) are more resistant to anit-in ammatory eect of Aspirin therapy than
white women (WAW)." Endocine Society's 96th Annual Meeting, Chicago, IL, Jun. 2014.
16. Motiwala T, Mustafa M, Kutay H, Sullivan RC, Teng KY, Chowdhary V, Yu L, Ghoshal
K, Jacob S. "Elucidation of the role of microRNA-155 in a murine model of non-alcoholic
steatohepatitis." 105th Annual Meeting of the American Association for Cancer Research,
San Diego, CA, Apr. 2014.
17. Pitarresi JR, Wu J, Woelke S, Kladney R, Cuitino M, Yu L, Ostrowski OC. Ets-2 acts
as as novel oncogene in cancer associated broblasts and promotes pancreatic tumor
initiation and development. AACR, New Orleans, May 2014.
18. Yu L, Zhang J. Sample size calculation for high-dimensional count data. OSU BMI
retreat, Mar. 2014.
19. Yu L, Zhang J. Sample size calculation for high-dimensional count data. OSU-Cleveland
joint symposium, May 2014.
20. Yu L. Challenges and Strategies in high-dimensional genomic data analysis with small
sample sizes. BMI seminar, Apr. 2014.
21. Yu L and Jarjoura, D. "Variance smoothing with multiple groups via fully moderated
t-statistic." Joint Statistical Meeting, Montreal, Aug. 2013.
22. Yu L. "Integration of omics data". The Ohio State University Center for Clinical and
Translational Science Genomic Medicine Conference, Apr. 2013.
23. Yu L, Jarjoura D, Pringle D, Kirschner L. "Identifying inconsistencies and consistencies
between mouse models and human cancers using high dimensional data." Joint Statistical
Meeting, San Diego, Aug. 2012.
11
24. Kota J, Hsu SH, Wang B, Kutay H, Costinean S, Bai S, Yu L, La Perle K, Chivukula RR,
Clark KR, Jacob S, Mendell JR, Ghoshal K, Mendell, JT. "Tumor suppressor proterties
of miR-122 and its biological function in mouse liver." American Society of Gene and Cell
Therapy's 14th Annual Meeting In Seattle, Washington.
25. Yu L,Jarjoura D and Fernandez S. "Statistical problems in microarray data analysis with
small sample sizes." The Ohio State University Compresensive Cancer Center Shared
Resources Workshop, Sep. 2010.
26. Gulati P, Jarjoura D, Fernandez S, Yu L and Pennell M. "An improved variance-smoothing
method for testing dierential expression in small-sample-size aymetrix oligonucleotide
microarrays." Joint Statistical Meeting, Vancouver CA, Aug. 2010.
27. Gulati P, Jarjoura D, Fernandez S, Yu L and Pennell M. "Variance-smoothing method for
testing dierential expression in aymetrix oligonucleotide microarrays." Joint Statistical
Meeting, Washington D.C., Aug. 2009.
28. Yu L, Jarjoura D and Fernandez S. "Statistical problems in microarray data analysis
with small sample sizes." The Ohio State University Compresensive Cancer Center Shared
Resources Workshop, Mar. 2009. Yu L, Ruppert AS, Jarjour D, Rao Y, Hua K, Lee Y
and Hsu J. "Overcoming multiple testing with small sample sizes." The 9th Annual OSU
Comprehensive Cancer Center Scientic Meeting, Feb. 2007.
29. Yu L and Doerge RW. "Statistical issues in protein microarray data analysis.", Bioinfor-
matics Seminar, Purdue University, 2006.
30. Yu L, Hewitt SM, Skacel M, Klein EA and Doerge RW. "Application of tissue microarrays
to study proteins in prostate cancer." Conference on Applied Statistics in Agriculture,
Kansas State University, Apr. 2005.
31. Yu L, Haab BB and Doerge RW. "Statistical analysis of protein microarray data." Joint
Statistical Meetings, Toronto CA, Aug. 2004.
32. Yu L, Haab BB and Doerge RW. "Reproducibility and analysis of protein microarray."
First Annual Indiana Bioinformatics Conference, Indianapolis IN, May 2004.
33. Yu L, Haab BB and Doerge RW. "Reproducibility and analysis of protein microarray."
Conference on Applied Statistics in Agriculture, Kansas State University, Apr. 2004.